Ergocalciferol

Ergocalciferol
IUPAC name

(3β,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
Other names

Drisdol (Sanofi-Synthelabo), Calcidol (Patrin Pharma)
Identifiers
CAS number 50-14-6 Y
PubChem 5280793
ChemSpider 4444351 Y
UNII VS041H42XC Y
DrugBank DB00153
KEGG C05441 Y
ChEBI CHEBI:28934 Y
ChEMBL CHEMBL1536 Y
Jmol-3D images Image 1
Properties
Molecular formula C28H44O
Molar mass 396.65 g/mol
Melting point

114–118 °C
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Ergocalciferol is a form of vitamin D, also called vitamin D2. It is marketed under various names including Deltalin (Eli Lilly and Company), Drisdol (Sanofi-Synthelabo) and Calcidol (Patrin Pharma). It is created from viosterol, which in turn is created when ultraviolet light activates ergosterol (which is found in fungi and named as a sterol from ergot) and so comes only from plants.

Ergocalciferol is widely used as a Vitamin D supplement, and a 2011 clinical guideline[1] considers it to be as effective as cholecalciferol (Vitamin D3), which is produced naturally by the skin when it is exposed to ultraviolet light. However there is now conflicting evidence regarding how similarly D2 and D3 behave in the body and whether they are equally potent. Some studies suggest D3 is more potent,[2][3] but others have found that they are equally effective.[4][5]

References

  1. ^ Holick, M. F.; Binkley, N. C.; Bischoff-Ferrari, H. A.; Gordon, C. M.; Hanley, D. A.; Heaney, R. P.; Murad, M. H.; Weaver, C. M. (2011). "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline". Journal of Clinical Endocrinology & Metabolism 96 (7): 1911. doi:10.1210/jc.2011-0385. PMID 21646368.  edit
  2. ^ Houghton, L.; Vieth, R. (2006). "The case against ergocalciferol (vitamin D2) as a vitamin supplement". The American Journal of Clinical Nutrition 84 (4): 694–697. PMID 17023693.  edit
  3. ^ Trang, H. M.; Cole, D. E.; Rubin, L. A.; Pierratos, A.; Siu, S.; Vieth, R. (1998). "Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2". The American journal of clinical nutrition 68 (4): 854–858. PMID 9771862.  edit
  4. ^ Holick, M. F.; Biancuzzo, R. M.; Chen, T. C.; Klein, E. K.; Young, A.; Bibuld, D.; Reitz, R.; Salameh, W. et al. (2007). "Vitamin D2 is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D". Journal of Clinical Endocrinology & Metabolism 93 (3): 677. doi:10.1210/jc.2007-2308. PMC 2266966. PMID 18089691. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2266966.  edit
  5. ^ Biancuzzo, R. M.; Young, A.; Bibuld, D.; Cai, M. H.; Winter, M. R.; Klein, E. K.; Ameri, A.; Reitz, R. et al. (2010). "Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults". American Journal of Clinical Nutrition 91 (6): 1621–1626. doi:10.3945/ajcn.2009.27972. PMC 2869510. PMID 20427729. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2869510.  edit

External links

Fat soluble
Tocopherol (Alpha, Beta, Gamma, Delta) · Tocotrienol (Alpha, Beta, Gamma, Delta)  · Tocofersolan
Water soluble
Combinations

M: NUT

cof, enz, met

noco, nuvi, sysi/epon, met

drug(A8/11/12)